Amorolfine HCL

CAS No. 106614-68-0

Amorolfine HCL ( —— )

Catalog No. M22881 CAS No. 106614-68-0

Amorolfine HCL is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell membrane. Amorolfine, a morpholine antifungal drug, can inhibit D14 reductase and D7-D8 isomerase.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Amorolfine HCL
  • Note
    Research use only, not for human use.
  • Brief Description
    Amorolfine HCL is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell membrane. Amorolfine, a morpholine antifungal drug, can inhibit D14 reductase and D7-D8 isomerase.
  • Description
    Amorolfine HCL is an antifungal reagent. It exerts the antifungal activity by selectively interrupting two steps in the pathway of ergosterol synthesis and eventually disrupting the function and structure of fungal cell membrane. Amorolfine, a morpholine antifungal drug, can inhibit D14 reductase and D7-D8 isomerase. These enzymes can deplete ergosterol and cause ignosterol to accumulate in the fungal cytoplasmic cell membranes.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Antibacterial
  • Recptor
    Antibiotic
  • Research Area
    Immune system/Infection
  • Indication
    Onychomycosis

Chemical Information

  • CAS Number
    106614-68-0
  • Formula Weight
    354
  • Molecular Formula
    C21H36ClNO?
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:12.5 mg/mL (35.31 mM; Need ultrasonic);H2O:3.33 mg/mL (9.41 mM; Need ultrasonic)
  • SMILES
    CCC(C)(C)C1=CC=C(C=C1)CC(C)CN2CC(OC(C2)C)C.Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Espinel-Ingroff A, et al. Antimicrob Agents ChemOthers. 1984 Jul; 26(1):5-9.
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